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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-PBZ1038
PBZ1038

Chemical Structure : PBZ1038

CAS No.: 2043687-46-1

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PBZ1038 (PBZ 1038)

货号: PC-22848Not For Human Use, Lab Use Only.

PBZ1038 is a small-molecule inhibitor of the GroES/GroEL chaperone system with IC50 of 1.2 uM against E. faecium GroES/GroEL refolding of malate dehydrogenase (MDH), binds at the GroEL ring–ring interface (RRI).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PBZ1038 is a small-molecule inhibitor of the GroES/GroEL chaperone system with IC50 of 1.2 uM against E. faecium GroES/GroEL refolding of malate dehydrogenase (MDH), binds at the GroEL ring–ring interface (RRI).
PBZ1038 engagement of GroES/GroEL in bacteria leads to antibiotic activity.
PBZ1038 potently inhibit the refolding activity of E. coli and the Gram-negative ESKAPE pathogen GroES/GroEL but not the Gram-positive ESKAPE pathogen E. faecium GroES/GroEL.
PBZ1038 shows a robust shift in CC50 in the presence of E. faecium chaperonin and a shift in EC50 in the eGFP reporter assay in the presence of E. faecium chaperonin.

物理化学性质&存储条件

分子量 537.56
分子式 C25H19N3O7S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-hydroxy-N-(4-(5-((4-hydroxyphenyl)sulfonamido)benzo[d]oxazol-2-yl)phenyl)benzenesulfonamide

参考文献

1. Jack Godek, et al. J Am Chem Soc. 2024 Jul 31;146(30):20845-20856.

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