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PBT434 mesylate

Chemical Structure : PBT434 mesylate

CAS No.: 2387898-69-1

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PBT434 mesylate (ATH434 mesylate)

货号: PC-27216Not For Human Use, Lab Use Only.

PBT434 mesylate is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease.

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5 mg ￥3580 In stock
10 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PBT434 mesylate is a novel quinazolinone compound with effect of lowering cellular iron levels, prevents iron mediated neurodegeneration and α-synuclein toxicity in multiple models of Parkinson disease.
PBT434 inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein, a protein that aggregates in the neuropathology.
PBT434 prevents loss of substantia nigra pars compacta neurons (SNpc), lowers nigral α-synuclein accumulation, and rescues motor performance in mice model of PD.

物理化学性质&存储条件

分子量 398.26
分子式 C13H17Cl2N3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4(3H)-Quinazolinone, 5,7-dichloro-2-[(ethylamino)methyl]-8-hydroxy-3-methyl-, methanesulfonate (1:1)

参考文献

1. Finkelstein DI, et al. Acta Neuropathol Commun. 2017 Jun 28;5(1):53.

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