PBRM1 inhibitor PB16 | PBRM1-BD2 inhibitor | Probechem Biochemicals

Chemical Structure : PBRM1 inhibitor PB16

CAS No.: 2819989-61-0

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PBRM1 inhibitor PB16 (PBRM1-BD2 inhibitor 16)

货号: PC-25802Not For Human Use, Lab Use Only.

PBRM1 inhibitor PB16 is a selective, cell-active Polybromo-1 (PBRM1) bromodomain inhibitor with ITC KD of 2 uM for PBRM1-BD2, and IC50 of 0.26 uM in AlphaScreen assays.

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2 mg	￥1480	In stock
5 mg	￥2580	In stock
10 mg	￥4280	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PBRM1 inhibitor PB16 is a selective, cell-active Polybromo-1 (PBRM1) bromodomain inhibitor with ITC KD of 2 uM for PBRM1-BD2, and IC50 of 0.26 uM in AlphaScreen assays.
PB16 does not bind the SMARCA2 and SMARCA4 bromodomains.
PB16 shows promising inhibition toward PBRM1-dependent prostate cancer cell line LNCaP with IC50 of 9 uM.

物理化学性质&存储条件

分子量	272.73
分子式	C15H13ClN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-Chloro-2-(3-methylphenyl)-2,3-dihydroquinazolin-4(1H)-one

参考文献

1. Nuñez R, et al. ACS Med Chem Lett. 2025 Sep 16;16(10):1955-1962.

2. Shishodia S, et al. J Med Chem. 2022 Oct 27;65(20):13714-13735.

PBRM1 inhibitor PB16 (PBRM1-BD2 inhibitor 16)

生物&药学活性

物理化学性质&存储条件

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PBRM1 inhibitor PB16 (PBRM1-BD2 inhibitor 16)

生物&药学活性

物理化学性质&存储条件

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