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首页-小分子抑制剂&激动剂-GPCR-GPR84-PBI-4547
PBI-4547

Chemical Structure : PBI-4547

CAS No.: 1627694-81-8

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PBI-4547 (PBI4547)

货号: PC-72358Not For Human Use, Lab Use Only.

PBI-4547 is an agonist of GPR40/120 and an antagonist of GPR84, also is a partial ligand and activator of PPAR.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PBI-4547 is an agonist of GPR40/120 and an antagonist of GPR84, also is a partial ligand and activator of PPAR.
    PBI-4547 dose-dependently inhibits GPR84/Gαi2 activation (reflected by an increase in BRET signal) with IC50 of 17 uM, activates GPR40 (EC50 of 102 µM for Gαq and 16 µM for Gαi2) and dose-dependently promoted β-arrestin-2 recruitment to GPR120 (EC50=148 uM).
    PBI-4547 prevents progression, improves glucose metabolism in a mouse model of NAFLD, restores hepatic glucose and FA metabolism.

    物理化学性质&存储条件

    分子量 298.402
    分子式 C18H27NaO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    Benzeneacetic acid, 3,5-dipentyl-, sodium salt (1:1)

    参考文献

    1. Simard JC, et al. Sci Rep. 2020 Jul 29;10(1):12778.

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