Chemical Structure : PBI-4050
货号: PC-35464Not For Human Use, Lab Use Only.
PBI-4050 (Setogepram, Fezagepras) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.
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PBI-4050 (Setogepram, Fezagepras) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.
PBI-4050 significantly attenuated fibrosis in many injury contexts, as evidenced by the antifibrotic activity observed in kidney, liver, heart, lung, pancreas, and skin fibrosis models;.
PBI-4050 is a first-in-class compound that may be effective for managing inflammatory and fibrosis-related diseases.
分子量 | 206.285 | |
分子式 | C13H18O2 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
1. Gagnon L, et al. Am J Pathol. 2018 May;188(5):1132-1148.
2. Li Y, et al. JCI Insight. 2018 May 17;3(10). pii: 120365.
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