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首页-小分子抑制剂&激动剂-GPCR-Free Fatty Acid Receptor (FFAR)-PBI-4050
PBI-4050

Chemical Structure : PBI-4050

CAS No.: 1002101-19-0

PBI-4050 (Fezagepras, Setogepram, PBI4050)

货号: PC-35464Not For Human Use, Lab Use Only.

PBI-4050 (Setogepram, Fezagepras) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PBI-4050 (Setogepram, Fezagepras) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.
    PBI-4050 significantly attenuated fibrosis in many injury contexts, as evidenced by the antifibrotic activity observed in kidney, liver, heart, lung, pancreas, and skin fibrosis models;.
    PBI-4050 is a first-in-class compound that may be effective for managing inflammatory and fibrosis-related diseases.

    物理化学性质&存储条件

    分子量 206.285
    分子式 C13H18O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (3-pentylphenyl)acetic acid

    参考文献

    1. Gagnon L, et al. Am J Pathol. 2018 May;188(5):1132-1148.

    2. Li Y, et al. JCI Insight. 2018 May 17;3(10). pii: 120365.

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