PBI-4050 (Fezagepras, Setogepram) | GPR40 agonist, GPR84 antagonist

Chemical Structure : PBI-4050

CAS No.: 1002101-19-0

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PBI-4050 (Fezagepras, Setogepram, PBI4050)

货号: PC-35464Not For Human Use, Lab Use Only.

PBI-4050 (Setogepram, Fezagepras) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

PBI-4050 (Setogepram, Fezagepras) is a synthetic analog of a medium-chain fatty acid that displays agonist and antagonist ligand affinity toward GPR40 and GPR84, respectively.
PBI-4050 significantly attenuated fibrosis in many injury contexts, as evidenced by the antifibrotic activity observed in kidney, liver, heart, lung, pancreas, and skin fibrosis models;.
PBI-4050 is a first-in-class compound that may be effective for managing inflammatory and fibrosis-related diseases.

物理化学性质&存储条件

分子量	206.285
分子式	C13H18O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-pentylphenyl)acetic acid

参考文献

1. Gagnon L, et al. Am J Pathol. 2018 May;188(5):1132-1148.

2. Li Y, et al. JCI Insight. 2018 May 17;3(10). pii: 120365.

PBI-4050 (Fezagepras, Setogepram, PBI4050)

生物&药学活性

物理化学性质&存储条件

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PBI-4050 (Fezagepras, Setogepram, PBI4050)

生物&药学活性

物理化学性质&存储条件

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