PBENZ-DBRMD

Chemical Structure : PBENZ-DBRMD

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货号: PC-38162Not For Human Use, Lab Use Only.

PBENZ-DBRMD is a first-in-class inhibitor of enzyme iodothyronine deiodinase type 3 (DIO3) with antitumor effects both in vitro and in vivo.

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生物&药学活性

PBENZ-DBRMD is a first-in-class inhibitor of enzyme iodothyronine deiodinase type 3 (DIO3) with antitumor effects both in vitro and in vivo.
PBENZ-DBRMD demonstrated attenuated cell counts, induction in apoptosis, and a reduction in cell proliferation in DIO3-positive HGSOC cells (OVCAR3 and KURAMOCHI), but not in DIO3-negative normal ovary cells (CHOK1) and OVCAR3 depleted for DIO3 or its substrate, T3.

物理化学性质&存储条件

分子量	374.972
分子式	C11H5Br2NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(3,4-dibromo-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid

参考文献

1. Dotan Moskovich, et al. Oncogene. 2021 Nov;40(44):6248-6257.

PBENZ-DBRMD

生物&药学活性

物理化学性质&存储条件

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PBENZ-DBRMD

生物&药学活性

物理化学性质&存储条件

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