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首页-小分子抑制剂&激动剂-Others-Other Targets-PBD-150
PBD-150

Chemical Structure : PBD-150

CAS No.: 790663-33-1

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PBD-150 (PBD 150, PBD150)

货号: PC-60393Not For Human Use, Lab Use Only.

PBD150 is a potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM.

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5 mg ￥1180 In stock
10 mg ￥1780 In stock
25 mg ￥2980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PBD150 is a potent glutaminyl cyclase (QC) inhibitor with Ki of 60 nM.
PBD150 significantly reduces depositions of Aβ3(pGlu)-40/42 in brain in transgenic mouse models and Drosophila model of Alzheimer diseas.

物理化学性质&存储条件

分子量 320.411
分子式 C15H20N4O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3,4-dimethoxyphenyl)-3-(3-imidazol-1-ylpropyl)thiourea

参考文献

1. Cynis H, et al. Biochemistry. 2008 Jul 15;47(28):7405-13.

2. Huang KF, et al. J Biol Chem. 2011 Apr 8;286(14):12439-49.

3. Buchholz M, et al. J Med Chem. 2006 Jan 26;49(2):664-77.

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