PAX inhibitor BG1 | Pax-2 inhibitor | Probechem Biochemicals

Chemical Structure : PAX inhibitor BG1

CAS No.: 951536-07-5

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PAX inhibitor BG1 (PAX-IN-BG1)

货号: PC-72554Not For Human Use, Lab Use Only.

PAX inhibitor BG1 (PAX-IN-BG1) is a small molecule inhibitor that attenuate Pax-2 transactivation ability with IC50 of 1.5 uM.

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5 mg	￥2980	In stock
10 mg	￥4580	In stock
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生物&药学活性

PAX inhibitor BG1 (PAX-IN-BG1) is a small molecule inhibitor that attenuate Pax-2 transactivation ability with IC50 of 1.5 uM.
BG1 also shows ability to inhibit Pax5 and Pax8 activation of the PRS4-Luc reporter assays.
BG1 inhibits Pax2-positive cancer cell growth and target gene expression but has little effect on Pax2-negative cells.
BG1 prevent Pax protein interactions with the histone H3K4 methylation complex at Pax target genes (Cdh6) in renal cells.

物理化学性质&存储条件

分子量	336.443
分子式	C19H24N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(4-(2,5-dimethylphenyl)piperazin-1-yl)-5,6-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine

参考文献

1. Shayna T J Bradford, et al. Cell Chem Biol. 2021 Nov 18;S2451-9456(21)00480-3.

PAX inhibitor BG1 (PAX-IN-BG1)

生物&药学活性

物理化学性质&存储条件

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PAX inhibitor BG1 (PAX-IN-BG1)

生物&药学活性

物理化学性质&存储条件

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