PAWI-2 | Wnt inhibitor | Probechem Biochemicals

Chemical Structure : PAWI-2

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PAWI-2 (Wnt-p53 inhibitor compound 2)

货号: PC-35498Not For Human Use, Lab Use Only.

PAWI-2 is a small molecule inhibitor targets both Wnt signaling and ATM/p53, potently inhibits Wnt transcription (IC50=11 nM) and p53 transcription (EC50=1.9 nM).

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生物&药学活性

PAWI-2 is a small molecule inhibitor targets both Wnt signaling and ATM/p53, potently inhibits Wnt transcription (IC50=11 nM) and p53 transcription (EC50=1.9 nM).
PAWI-2 decreases HCT-116 CRC cell viability (IC50=10 nM) and proliferation (IC50=8 nM), decreases DLD-1, SW480 and 10.1 cancer cell viability (IC50=12, 27 and 41 nM) and proliferation (IC50=18,15 and 13 nM).
PAWI-2 potently activates apoptosis of HCT-116, DLD-1 and SW480 cells (EC50=13, 15 and 18 nM) in a p53-dependent manner; inhibits cell migration and invasion in HCT-116 at 20-200 nM.
PAWI-2 also modulates mitotic stress signaling, leading to both inhibition of Wnt responsiveness and stabilization and activation of p53 to cause cell cycle arrest.
PAWI-2 induces cell death and inhibits tumor growth in mouse xenografts (20 mg/kg/day, i.p.), without acute cytotoxicity nor toxicity.

物理化学性质&存储条件

分子量	371.455
分子式	C19H21N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-((4-methyl-3,4-dihydroquinoxalin-1(2H)-yl)sulfonyl)phenyl)pyrrolidin-2-one

参考文献

1. Cheng J, et al. Cancer Res. 2018 Jul 21. pii: canres.2642.2017. doi: 10.1158/0008-5472.CAN-17-2642.
2. Cheng J, et al. J Pharmacol Exp Ther. 2019 Dec;371(3):703-712.

PAWI-2 (Wnt-p53 inhibitor compound 2)

生物&药学活性

物理化学性质&存储条件

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PAWI-2 (Wnt-p53 inhibitor compound 2)

生物&药学活性

物理化学性质&存储条件

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