PAV-431 | Viral assembly modulator | Probechem Biochemicals

Chemical Structure : PAV-431

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PAV-431 (PAV431)

货号: PC-22550Not For Human Use, Lab Use Only.

PAV-431 is a small molecule pan-respiratory viral assembly modulator with EC50 of <100 nM against multiple viruses in cell culture, directly binds to host protein 14-3-3.

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生物&药学活性

PAV-431 is a small molecule pan-respiratory viral assembly modulator with EC50 of <100 nM against multiple viruses in cell culture, directly binds to host protein 14-3-3.
PAV-431 displayed an EC50 between 25nM and 100nM (depending on the virus) against members of Orthomyxoviridae, Coronaviridae, Paramyxoviridae, Adenoviridae, Herpesviridae, and Picornaviridae-all six families of viruses which cause respiratory disease in humans.
PAV-431 shows efficacy against the WA 1/2020, delta, and omicron strains of SARS CoV-2.
PAV-431 does not show significant activity against rabies virus.
PAV-431 treatment exhibits statistically significant drop in RSV titer in cotton rats infected with respiratory syncytial virus (RSV).

物理化学性质&存储条件

分子量	369.34
分子式	C17H18F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-cyclopropyl-N-(2-methoxy-3-(trifluoromethoxy)benzyl)-1-methyl-1H-pyrazole-5-carboxamide

参考文献

1. Michon M, et al. bioRxiv [Preprint]. 2023 Dec 12:2021.01.17.426875.

PAV-431 (PAV431)

生物&药学活性

物理化学性质&存储条件

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PAV-431 (PAV431)

生物&药学活性

物理化学性质&存储条件

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