PAV-206 | HIV-1 inhibitor | Probechem Biochemicals

Chemical Structure : PAV-206

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PAV-206 (PAV206)

货号: PC-49168Not For Human Use, Lab Use Only.

PAV-206 is a novel potent antiretroviral chemotype that inhibits HIV-1 replication with EC50 of 34 nM in HIV-1-infected MT-2 T cells, and 75 nM in HIV-1-infected peripheral blood mononuclear cells (PBMCs), inhibits HIV-1 replication by interfering with HIV-1 assembly.

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生物&药学活性

PAV-206 is a novel potent antiretroviral chemotype that inhibits HIV-1 replication with EC50 of 34 nM in HIV-1-infected MT-2 T cells, and 75 nM in HIV-1-infected peripheral blood mononuclear cells (PBMCs), inhibits HIV-1 replication by interfering with HIV-1 assembly.
PAV-206 acts on the host RNA-granule-related RNP complex that is the precursor of assembly intermediates, even in the absence of Gag, colocalizes with both of host enzymes, ABCE1 and DDX6, in the absence of HIV-1 infection.
PAV-206 is a first-in-class selective inhibitor of HIV-1 assembly that inhibits HIV-1 virus production by selectively acting on host-protein-containing capsid assembly intermediates.

物理化学性质&存储条件

分子量	445.559
分子式	C28H31NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-6-(benzyloxy)-1-(4,5-dimethoxy-2-methylstyryl)-7-methoxy-1,2,3,4-tetrahydroisoquinoline

参考文献

1. Reed JC, et al. J Virol. 2021 Jan 13;95(3):e00883-20.

PAV-206 (PAV206)

生物&药学活性

物理化学性质&存储条件

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PAV-206 (PAV206)

生物&药学活性

物理化学性质&存储条件

参考文献

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