PAV-104 | SARS-CoV-2 assembly inhibitor | Probechem Biochemicals

Chemical Structure : PAV-104

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PAV-104 (PAV104)

货号: PC-20900Not For Human Use, Lab Use Only.

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50 mg		Get quote
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1 g		Get quote

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生物&药学活性

PAV-104 (PAV104) is a novel viral assembly inhibitor, shows potent anti-SARS-CoV-2 activity in Calu-3 cells with EC50 of 1.7 nM and EC90 of 23.5 nM, inhibits the oligomerization of the SARS-CoV-2 nucleocapsid.
PAV-104 is more potent than remdesivir (EC50 =7.9 nM and EC90 =218.1 nM).
PAV-104 exerts potent antiviral activity against a broad range of circulating SARS-CoV-2 variants in human primary airway epithelial cells (AECs).
PAV-104 specifically inhibits virus-like particle production, and blocks SARS-CoV-2 replication through targeting the viral assembly/budding process.
PAV-104 interacts with N and interferes with nucleocapsid oligomerization.
PAV-104 suppresses the 'maturation of nucleoprotein' signaling pathway reinforces inhibition of viral assembly/budding.

物理化学性质&存储条件

分子量	581.69
分子式	C29H35N5O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=CC(C2CC2)=NN1C)NCC3=CC=CC(OCC4=CC=C(C(N5CCN(S(=O)(C)=O)CC5)=O)C=C4)=C3OC

参考文献

1. Satish Pillai, et al. Res Sq. 2023 May 17;rs.3.rs-2887435.

PAV-104 (PAV104)

生物&药学活性

物理化学性质&存储条件

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PAV-104 (PAV104)

生物&药学活性

物理化学性质&存储条件

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