PAT1inh-B01

Chemical Structure : PAT1inh-B01

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货号: PC-38753Not For Human Use, Lab Use Only.

PAT1inh-B01 is a small-molecule, selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor, could fully inhibit PAT1-mediated anion exchange with IC50 of 350 nM.

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生物&药学活性

PAT1inh-B01 is a small-molecule, selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor, could fully inhibit PAT1-mediated anion exchange with IC50 of 350 nM.
PAT1inh-B01 displays no inhibition of the related intestinal transporter SLC26A3 (also known as DRA).
In closed midjejunal loops in mice, PAT1inh-B01 inhibited fluid absorption by 50%, which increased to >90% when coadministered with DRA inhibitor DRAinh-A270.
PAT1inh-B01 blocked fluid absorption by >80% in ileal loops, SLC26A3 inhibitor DRAinh-A270 had no effect.
PAT1inh-B01 is a novel tool to study intestinal ion and fluid transport.

物理化学性质&存储条件

分子量	535.325
分子式	C22H18BrF3N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-[2-[4-Bromo-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]acetyl]-5,6,7,8-tetrahydro-2-phenylpyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one

参考文献

1. Cil O, et al. JCI Insight. 2021 Jun 8;6(11):e147699.

2. Lee S, et al. J Med Chem. 2019;62(17):8330–8337.

PAT1inh-B01

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物理化学性质&存储条件

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PAT1inh-B01

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