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首页-小分子抑制剂&激动剂-Others-Other Targets-PAT1inh-A0030
PAT1inh-A0030

Chemical Structure : PAT1inh-A0030

CAS No.: 1030097-65-4

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PAT1inh-A0030

货号: PC-21358Not For Human Use, Lab Use Only.

PAT1inh-A0030 is a potent and selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor with IC50 of 1.0 uM, shows no activity on relevant ion transporters/channels (SLC26A3, SLC26A4, SLC26A9, CFTR, TMEM16A).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PAT1inh-A0030 is a potent and selective SLC26A6 (putative anion transporter 1, PAT1) inhibitor with IC50 of 1.0 uM, shows no activity on relevant ion transporters/channels (SLC26A3, SLC26A4, SLC26A9, CFTR, TMEM16A).
PAT1inh-A0030 inhibited fluid absorption in the ileum of wild-type and CF mice (CftrdelF508/delF508) with >90% prevention of a decrease in loop fluid volume and loop weight/length ratio in a closed-loop model of intestinal fluid absorption.

物理化学性质&存储条件

分子量 326.36
分子式 C17H18N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

ethyl 4-(benzyl(methyl)amino)-3-methylisoxazolo[5,4-d]pyrimidine-6-carboxylate

参考文献

1. Tifany Chu, et al. RSC Med Chem. 2023 Sep 14;14(11):2342-2347.

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