PAT-505 sodium

Chemical Structure : PAT-505 sodium

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货号: PC-23710Not For Human Use, Lab Use Only.

PAT-505 sodium (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX.

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生物&药学活性

PAT-505 sodium (PAT 505, PAT505) is a potent, selective, noncompetitive, and orally active autotaxin inhibitor with IC50 of 2.0 nM against the lysoPLD activity of human ATX.
PAT-505 displays high selectivity over other ENPP proteins and no significant agonist or antagonist activity at PPARα and PPARγ.
PAT-505 maintains good potency for inhibition of lysoPLD activity with IC50 of 9.7 nM and 62 nM in human blood and mouse plasma, respectively.
PAT-505 robustly reduces liver fibrosis with no significant effect on steatosis, hepatocellular ballooning, or inflammation in high-fat diet model of NASH.

物理化学性质&存储条件

分子量	495.90
分子式	C23H17ClF2N3NaO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((6-chloro-2-cyclopropyl-1-(1-ethyl-1H-pyrazol-4-yl)-7-fluoro-1H-indol-3-yl) thio)-2-fluorobenzoic acid sodium salt

参考文献

1. Bain G, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13.

PAT-505 sodium

生物&药学活性

物理化学性质&存储条件

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PAT-505 sodium

生物&药学活性

物理化学性质&存储条件

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