PAT-048 |CAS:1359983-15-5 Probechem Biochemicals

Chemical Structure : PAT-048

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PAT-048 (PAT 048;PAT048)

货号: PC-60639Not For Human Use, Lab Use Only.

PAT-048 (PAT048) is a potent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX.

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生物&药学活性

PAT-048 (PAT048) is a potent, selective, noncompetitive autotaxin inhibitor with IC50 of 1.1 nM against the lysoPLD activity of human ATX.
PAT-048 exhibits good potency for inhibition of lysoPLD activity with IC50 of 8.9 nM and 22 nM in human blood and mouse plasma, respectively.
PAT-048 decreases ATX activity systemically and in the lung, without effect on pulmonary LPA or fibrosis in bleomycin-challenged mice.

物理化学性质&存储条件

分子量	461.912
分子式	C22H18ClF2N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((6-chloro-7-fluoro-2-methyl-1-(1-propyl-1H-pyrazol-4-yl)-1H-indol-3-yl)thio)-2-fluorobenzoic acid

参考文献

1. Black KE, et al. FASEB J. 2016 Jun;30(6):2435-50.

2. Castelino FV, et al. Arthritis Rheumatol. 2016 Dec;68(12):2964-2974.

3. Bain G, et al. J Pharmacol Exp Ther. 2017 Jan;360(1):1-13.

PAT-048 (PAT 048;PAT048)

生物&药学活性

物理化学性质&存储条件

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PAT-048 (PAT 048;PAT048)

生物&药学活性

物理化学性质&存储条件

参考文献

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