PARP10 inhibitor 22 |CAS 2286261-72-9 Probechem Biochemicals

Chemical Structure : PARP10 inhibitor 22

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PARP10 inhibitor 22

货号: PC-36012Not For Human Use, Lab Use Only.

PARP10 inhibitor 22 is a selective, cell-active inhibitor of PARP10 with IC50 of 1.8 uM, exhibits >10-fold selectivity over a large subset of other PARP family members.

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100 mg		Get quote
250 mg		Get quote
500 mg		Get quote
1 g		Get quote

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生物&药学活性

PARP10 inhibitor 22 is a selective, cell-active inhibitor of PARP10 with IC50 of 1.8 uM, exhibits >10-fold selectivity over a large subset of other PARP family members.
PARP10 inhibitor 22 inhibits PARP10-dependent MARylation in cells.
PARP10 inhibitor 22 is a useful probe to study PARP10 biology when combined with other PARP10-selective probes with different selectivity profiles.

物理化学性质&存储条件

分子量	306.288
分子式	C16H13F3N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-methyl-6-(2-(trifluoromethyl)pyridin-4-yl)-3,4-dihydroisoquinolin-1(2H)-one

参考文献

1. Morgan RK, et al. ACS Med Chem Lett. 2018 Nov 29;10(1):74-79.