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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-PARP-PARP-1 inhibitor Pip5
PARP-1 inhibitor Pip5

Chemical Structure : PARP-1 inhibitor Pip5

CAS No.: 2101323-42-4

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PARP-1 inhibitor Pip5

货号: PC-21163Not For Human Use, Lab Use Only.

PARP-1 inhibitor Pip5 is an analog of PARP-1 type I inhibitor AZ0108, inhibits PARP-1 auto-PARylation with IC50 of 4-17 nM, shows similar type I inhibition of PARP-1 but is more cytotoxic than AZ0108.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PARP-1 inhibitor Pip5 is an analog of PARP-1 type I inhibitor AZ0108, inhibits PARP-1 auto-PARylation with IC50 of 4-17 nM, shows similar type I inhibition of PARP-1 but is more cytotoxic than AZ0108.

物理化学性质&存储条件

分子量 468.44
分子式 C23H19F3N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-(3-(3-(1,1-difluoroethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one

参考文献

1. Moriah R Arnold, et al. Cell Chem Biol. 2022 Dec 15;29(12):1694-1708.e10.

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