PAR4-AP TFA | PAR4 agonist | Probechem Biochemicals

Chemical Structure : PAR4-AP TFA

CAS No.: 1228078-65-6

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PAR4-AP TFA (AYPGKF-NH2, PAR4 agonist peptide)

货号: PC-27324Not For Human Use, Lab Use Only.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

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生物&药学活性

PAR4 Agonist Peptide AYPGKF-NH2 TFA (PAR4-AP) is a potent, PAR4-selective agonist peptide, stimulates platelet aggregation in vitro with EC50 of 15 uM, shows no significant interaction with either PAR1 or PAR2.
AYPGKF activates and desensitizes PAR4 in platelets and, like thrombin, triggers phosphoinositide hydrolysis but not inhibition of adenylyl cyclase in PAR4-expressing cells.
AYPGKF is more potent than the native GYPGKF sequence at stimulating PAR4-mediated phosphoinositide hydrolysis.
AYPGKF effectively desensitizes PAR4-mediated signaling in human platelets.

物理化学性质&存储条件

分子量	680.81
分子式	C34H48N8O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ala-Tyr-Pro-Gly-Lys-Phe-NH2

参考文献

1. Zhikang Xu, et al. Cell Rep. 2026 Jun 30;45(7):117632.

PAR4-AP TFA (AYPGKF-NH2, PAR4 agonist peptide)

生物&药学活性

物理化学性质&存储条件

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PAR4-AP TFA (AYPGKF-NH2, PAR4 agonist peptide)

生物&药学活性

物理化学性质&存储条件

参考文献

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