PAR1 inhibitor Q94

Chemical Structure : PAR1 inhibitor Q94

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货号: PC-49647Not For Human Use, Lab Use Only.

Q94 is a selective PAR1 antagonist and allosteric modulator that selectively block PAR(1) /Gα(q) interaction and signalling.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Q94 is a selective PAR1 antagonist and allosteric modulator that selectively block PAR(1) /Gα(q) interaction and signalling.
Q94 caused an approximately fourfold decrease in thrombin EC50 value, did not alter the Ca(2+) response mediated by a PAR(2) activating peptide.
Q94 suppressed the doxorubicin-induced increase in activities of caspase-9 and caspase-3 in podocytes.
Q94 treatment significantly attenuated periodic acid-Schiff and desmin staining, indicators of podocyte injury, and also decreased glomerular levels of podocin and nephrin in mouse model of nephropathy.

物理化学性质&存储条件

分子量	369.29
分子式	C21H18Cl2N2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Benzimidazole, 1-[(4-chlorophenyl)methyl]-2-(phenylmethyl)-, hydrochloride (1:1)

参考文献

1. Asteriti S, et al. Br J Pharmacol. 2012 Sep;167(1):80-94.

2. Guan Y, et al. J Pharmacol Sci. 2017 Sep 14:S1347-8613(17)30128-7.