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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Chloride Channel-PAM_16A
PAM_16A

Chemical Structure : PAM_16A

CAS No.: 2367645-32-5

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PAM_16A (PAM-16A)

货号: PC-23881Not For Human Use, Lab Use Only.

PAM_16A is a potent, selective, positive allosteric modulator of TMEM16A (Anoctamin-1, ANO1) with EC50 of 3.6 nM, activates heterologous TMEM16A channels, has no effect on the closely related TMEM16B channel.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PAM_16A is a potent, selective, positive allosteric modulator of TMEM16A (Anoctamin-1, ANO1) with EC50 of 3.6 nM, activates heterologous TMEM16A channels, has no effect on the closely related TMEM16B channel.
PAM_16A is a potent activator that does not interfere with other measurable whole-cell currents in arterial smooth muscle cells (SMCs).
PAM_16A selectively activated TMEM16A currents in SMCs and enhanced aortic contraction caused by phenylephrine or angiotensin-II and capillary (pericyte) constriction evoked by endothelin-1 or oxygen–glucose deprivation (OGD) to simulate cerebral ischaemia.

物理化学性质&存储条件

分子量 371.82
分子式 C19H18ClN3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[[2-(5-chloro-2-hydroxy-phenyl)acetyl]amino]-N-(1,1-dimethylprop-2-ynyl)pyridine-2-carboxamide

参考文献

1. Patent WO2021/014168, compound 1.

2. Al-Hosni R, et al. Br J Pharmacol. 2025 Jan 19. doi: 10.1111/bph.17383.

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