PAD4 inhibitor YJ-2

Chemical Structure : PAD4 inhibitor YJ-2

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货号: PC-27307Not For Human Use, Lab Use Only.

PAD4 inhibitor YJ-2 is a potent small molecule peptidylarginine deiminase 4 (PAD4) inhibitor with IC50 of 0.836 uM, approximately 7-fold more potent than Cl-amidine and superior to BB-Cl-amidine.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PAD4 inhibitor YJ-2 is a potent small molecule peptidylarginine deiminase 4 (PAD4) inhibitor with IC50 of 0.836 uM, approximately 7-fold more potent than Cl-amidine and superior to BB-Cl-amidine.
YJ-2 reduced NET-mediated neuronal death and oxidative stress in vitro, and improved endothelial barrier integrity.
YJ-2 significantly lowered infarct volume (44.2% → 30.6%), improved neurological function, and suppressed apoptosis in MCAO/R rats.

物理化学性质&存储条件

分子量	416.91
分子式	C21H25ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(benzylamino)-5-(2-chloroacetimidamido)-1-oxopentan-2-yl)-4-hydroxybenzamide

参考文献

1. Bicker KL, et al. ACS Med. Chem. Lett 3 (12) (2012) 1081–1085.

2. Jia Y, et al. Biomed. Pharmacother 168 (2023) 115826, 10.1016/j.biopha.2023.115826.

3. Yijiang Jia, et al. CNS Neurosci Ther. 2026 Jul;32(7):e71032.