PAD4 inhibitor 24

首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Arginine Deiminase (PAD)-PAD4 inhibitor 24

Chemical Structure : PAD4 inhibitor 24

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货号: PC-20330Not For Human Use, Lab Use Only.

PAD4 inhibitor 24 is a highly potent PAD4 inhibitor kinact/KI value of 54,000±3,000, displays >10-fold selectivity for PAD4 over PAD3 and >50-fold over PAD1 and PAD2.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PAD4 inhibitor 24 is a highly potent PAD4 inhibitor kinact/KI value of 54,000±3,000, displays >10-fold selectivity for PAD4 over PAD3 and >50-fold over PAD1 and PAD2.
PAD4 inhibitor 24 (5-10 uM) inhibits PAD4-mediated H4 citrullination in HL-60 granulocytes after stimulation with the calcium ionophore A23187.
PAD4 inhibitor 24 is more potent than pan-PAD inhibitor Cl-amidine.

物理化学性质&存储条件

分子量	436.20
分子式	C18H22Cl4N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-(3-(4,5,6-trichloro-1-(cyclopentylmethyl)-1H-indazol-3-yl)propyl)acetimidamide

参考文献

1. Tjin CC, et al. ACS Med Chem Lett. 2018 Sep 14;9(10):1013-1018.

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