PAD2 inhibitor 32a (AFM32a)

Chemical Structure : PAD2 inhibitor 32a

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货号: PC-20326Not For Human Use, Lab Use Only.

PAD2 inhibitor 32a (AFM32a) is a potent, selective protein arginine deiminase 2 (PAD2) inhibitor with IC50 of EC50 of 8.3 uM in target engagement assays in HEK293/PAD2 cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

PAD2 inhibitor 32a (AFM32a) is a potent, selective protein arginine deiminase 2 (PAD2) inhibitor with IC50 of EC50 of 8.3 uM in target engagement assays in HEK293/PAD2 cells.
PAD2 inhibitor 32a exhibits 95-fold selectivity for PAD2 over PAD4 and 79-fold selectivity for PAD2 over PAD3, based on kinact/KI values.

物理化学性质&存储条件

分子量	480.54
分子式	C25H29FN6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1S)-1-(4-Ethoxy-1-methyl-1H-benzimidazol-2-yl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]-2,3-dihydro-3-oxo-1H-isoindole-4-carboxamide

参考文献

1. Muth A, et al. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017.