PACMA31 | PDI inhibitor | Probechem Biochemicals

Chemical Structure : PACMA31

CAS No.: 1401089-31-3

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PACMA31 (PDI inhibitor PACMA31, PACMA-31)

货号: PC-70360Not For Human Use, Lab Use Only.

PACMA31 is an orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

PACMA31 is an orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI.
PACMA31 significantly inhibits human ovarian cancer cells OVCAR-8, HEY, and OVCAR-8 growth with IC50 of 0.9, 1.4, and 0.32 uM.
PACMA31 significantly suppresses ovarian tumor growth without causing toxicity to normal tissues in mouse xenograft model of human OVCAR-8 ovarian cancer.

物理化学性质&存储条件

分子量	430.47
分子式	C21H22N2O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycylglycine ethyl ester

参考文献

1. Xu S, et al. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16348-53.

2. Vatolin S, et al. Cancer Res. 2016 Jun 1;76(11):3340-50.

PACMA31 (PDI inhibitor PACMA31, PACMA-31)

生物&药学活性

物理化学性质&存储条件

参考文献

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PACMA31 (PDI inhibitor PACMA31, PACMA-31)

生物&药学活性

物理化学性质&存储条件

参考文献

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