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PAC1 antagonist M65

Chemical Structure : PAC1 antagonist M65

CAS No.: 1872440-65-7

PAC1 antagonist M65 (M65 TFA)

货号: PC-27327Not For Human Use, Lab Use Only.

PAC1 antagonist M65 is a truncated variant of Maxadilan and potent, specific antagonist of PACAP type 1 receptor (PACAP/VIP receptor 1, PVR1, PAC1 receptor), blocks the VIP-induced cAMP accumulation in cultured rat cortical neurons.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

PAC1 antagonist M65 is a truncated variant of Maxadilan and potent, specific antagonist of PACAP type 1 receptor (PACAP/VIP receptor 1, PVR1, PAC1 receptor), blocks the VIP-induced cAMP accumulation in cultured rat cortical neurons.

物理化学性质&存储条件

分子量 4823.53
分子式 C205H326N64O61S5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Cys-Asp-Ala-Thr-Cys-Gln-Phe-Arg-Lys-Ala-Ile-Asp-Asp-Cys-Gln-Lys-Gln-Ala-His-His-Ser-Asn-Val-Pro-Gly-Asn-Ser-Val-Phe-Lys-Glu-Cys-Met-Lys-Gln-Lys-Lys-Lys-Glu-Phe-Lys-Ala-NH2 (Disulfide bridge:Cys1-Cys5,Cys14-Cys32)

参考文献

1. Uchida D, et al. Ann N Y Acad Sci. 1998 Dec 11;865:253-8.

2. Jansen-Olesen I, et al. Neuropeptides. 2014 Apr;48(2):53-64.

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