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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-RAR/RXR-PA452
PA452

Chemical Structure : PA452

CAS No.: 457657-34-0

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PA452 (PA 452)

货号: PC-20831Not For Human Use, Lab Use Only.

PA452 is a specific antagonist of retinoic X receptor (RXR) with pA2 value of 7.11.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

PA452 is a specific antagonist of retinoic X receptor (RXR) with pA2 value of 7.11.
PA452 inhibits the effect of Retinoic acid (RA) on Th1/Th2 development, inhibits the Troglitazone (TZ)-induced CK13 expression

物理化学性质&存储条件

分子量 439.60
分子式 C26H37N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

O=C(C1=CN=C(N(C2=C(OCCCCCC)C=C3C(C)(C)CCC(C)(C)C3=C2)C)N=C1)O

参考文献

1. Fujii S., et al. Bioorg. Med. Chem. Lett. 2010;20:5139–5142.

2. wata M, et al. Int Immunol. 2003 Aug;15(8):1017-25.

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