PA-915 | PAC1 receptor antagonist | Probechem Biochemicals

Chemical Structure : PA-915

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PA-915 (PA915)

货号: PC-49382Not For Human Use, Lab Use Only.

PA-915 (PA915) is a small-molecule, non-peptide antagonist of the PACAP type I (PAC1) receptor, inhibits PACAP (1 nM)-induced phosphorylation of CREB in PAC1/CHO cells with IC50 of <10 pM.

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生物&药学活性

PA-915 (PA915) is a small-molecule, non-peptide antagonist of the PACAP type I (PAC1) receptor, inhibits PACAP (1 nM)-induced phosphorylation of CREB in PAC1/CHO cells with IC50 of <10 pM.
PA-915 is more potent than PA-9 on the PACAP-induced phosphorylation of CREB in the PAC1/CHO cells.
PA-915 inhibited both pituitary adenylate cyclase-activating polypeptide (PACAP) and spinal nerve ligation-induced mechanical allodynia.
PA-915 also showed anti-allodynic effects following oral administration.

物理化学性质&存储条件

分子量	372.813
分子式	C17H17ClN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(1H-imidazol-4-yl)ethyl)-1-(7-chloro-1H-indazol-3-yl)-5-oxopyrrolidine-3-carboxamide

参考文献

1. Ichiro Takasaki, et al. Eur J Med Chem. 2020 Jan 15;186:111902.

2. Yusuke Shintani, et al. Biochem Biophys Res Commun. 2022 Nov 26;631:146-151.

PA-915 (PA915)

生物&药学活性

物理化学性质&存储条件

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PA-915 (PA915)

生物&药学活性

物理化学性质&存储条件

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