PA-8 | PAC1 antagonist | Probechem Biochemicals

Chemical Structure : PA-8

CAS No.: 878437-15-1

加入收藏

PA-8 (PAC1 antagonist PA-8)

货号: PC-72883Not For Human Use, Lab Use Only.

PA-8 (PAC1 antagonist PA-8) is a potent, specific small molecule antagonist of PACAP type I (PAC1) receptor.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

PA-8 (PAC1 antagonist PA-8) is a potent, specific small molecule antagonist of PACAP type I (PAC1) receptor.
PA-8 (1 nM) significantly and dose dependently attenuated PACAP (1 nM)-induced CREB phosphorylation in the CHO cells expressing PAC1, but not CHO cells expressing VPAC1, or VPAC2 receptors.
PA-8 also dose dependently inhibited PACAP-induced cAMP elevation with an IC50 of 2 nM.
PA-8 blocked PACAP-induced aversive responses and mechanical allodynia in mice.

物理化学性质&存储条件

分子量	342.36
分子式	C17H18N4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(4-(Allyloxy)-3-methoxyphenyl)-2-amino-5,8-dihydropyrido[2,3-d]pyrimidine-4,7(3H,6H)-dione

参考文献

1. Takasaki I, et al. J Pharmacol Exp Ther. 2018 Apr;365(1):1-8.

2. Takasaki I, et al. J Pharmacol Sci. 2019 Feb;139(2):129-132.

3. Shibato J, et al. Neural Plast. 2021 Aug 7;2021:2522454.

PA-8 (PAC1 antagonist PA-8)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

PA-8 (PAC1 antagonist PA-8)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.