P217564 |CAS: 2773337-26-9 Probechem Biochemicals

Chemical Structure : P217564

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P217564 (P0217564;P 217564)

货号: PC-62574Not For Human Use, Lab Use Only.

P 217564 is a potent, selective, irreversible second generation inhibitor of USP7 with IC50 of 0.48 uM, with similar potency against USP47 and no significant activity aginst other DUBs.

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1 g		Get quote

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生物&药学活性

P217564 is a potent, selective, irreversible second generation inhibitor of USP7 with IC50 of 0.48 uM, with similar potency against USP47 and no significant activity aginst other DUBs.
P217564 exhibits 10-fold increase in potency compared to P5091, selectively targets the catalytic cleft of USP7 and modifies its active site cysteine (C223) by forming a covalent adduct.
P217564 downregulates Foxp3 and Tip60 in Treg cells and impairs Treg functions, increases polyubiquitination of Foxp3, Tip60 and USP7, induces dose- and time-dependent apoptosis of Jurkat cells.

物理化学性质&存储条件

分子量	447.3
分子式	C16H12Cl2N2O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl (E)-4-(5-((2,3-dichlorophenyl)thio)-4-nitrothiophene-2-carboxamido)but-2-enoate

参考文献

1. Wang F, et al. PLoS One. 2017 Dec 13;12(12):e0189744.

2. Wang L, et al. EBioMedicine. 2016 Nov;13:99-112.

P217564 (P0217564;P 217564)

生物&药学活性

物理化学性质&存储条件

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P217564 (P0217564;P 217564)

生物&药学活性

物理化学性质&存储条件

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