P2119 | Spike RBD-ACE2 inhibitor | Probechem Biochemicals

Chemical Structure : P2119

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P2119 (P-2119)

货号: PC-38281Not For Human Use, Lab Use Only.

P2119 (P-2119) is an anticoronaviruse chemical probe that inhibit SARS-CoV-2 Spike binding to human ACE2 receptor.

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生物&药学活性

P2119 (P-2119) is an anticoronaviruse chemical probe that inhibit SARS-CoV-2 Spike binding to human ACE2 receptor.
P2119 inhibits infection by human coronaviruses, including SARS-CoV-2, and decreases the binding of spike glycoprotein to its receptor ACE2.
P2119 targets a conserved hydrophobic binding pocket in the RBD with the benzyl thiol-reducing moiety pointed directly toward Cys432.
P2119 inhibits the SARS-CoV-2 infection by shifting the spike glycoprotein redox scaffold.

物理化学性质&存储条件

分子量	511.583
分子式	C21H37NO11S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,2'R,3R,3'R,4R,4'R,5S,5'S)-6,6'-((2-(4-(mercaptomethyl)phenoxy)ethyl)azanediyl)bis(hexane-1,2,3,4,5-pentaol)

参考文献

1. Yunlong Shi, et al. Proc Natl Acad Sci U S A. 2022 Feb 8;119(6):e2120419119.

P2119 (P-2119)

生物&药学活性

物理化学性质&存储条件

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P2119 (P-2119)

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物理化学性质&存储条件

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