P11 | PAFAH inhibitor | Probechem Biochemicals

Chemical Structure : P11

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P11 (PAFAH inhibitor P11)

货号: PC-62386Not For Human Use, Lab Use Only.

PAFAH inhibitor P11 (P11) is a potent, selective platelet-activating factor acetylhydrolases PAFAH1b2 and PAFAH1b3 inhibitor with IC50 of 40 nM and 900 nM respectively.

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生物&药学活性

PAFAH inhibitor P11 (P11) is a potent, selective platelet-activating factor acetylhydrolases PAFAH1b2 and PAFAH1b3 inhibitor with IC50 of 40 nM and 900 nM respectively.
P11 blocks PAFAH1b2- and PAFAH1b3-mediated hydrolysis of the substrate PAF to lyso-PAF with IC50 values of 36 nM and 880 nM.
P11 impairs tumor cell survival; in situ-active and can be used to investigate the cellular functions of PAFAH1b2/3.

物理化学性质&存储条件

分子量	503.7
分子式	C30H33NO4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,6R)-rel-2-[4-(1,1-dimethylethyl)phenyl]-1,2,5,6-tetrahydro-6-(4-methylphenyl)-1-[(4-methylphenyl)sulfonyl]-3-pyridinecarboxylic acid

参考文献

1. Chang JW, et al. ACS Chem Biol. 2015 Apr 17;10(4):925-32.

P11 (PAFAH inhibitor P11)

生物&药学活性

物理化学性质&存储条件

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P11 (PAFAH inhibitor P11)

生物&药学活性

物理化学性质&存储条件

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