Oxythiamine chloride hydrochloride

Chemical Structure : Oxythiamine chloride hydrochloride

CAS No.: 614-05-1

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货号: PC-63371Not For Human Use, Lab Use Only.

Oxythiamine chloride is a small molecule transketolase inhibitor with Kd of 33 nM, shows functional assay of human transketolase inhibition in HCT-116 cells with EC50 of 26 nM.

规格	价格	库存
100 mg	￥580	In stock
250 mg	￥980	In stock
1 g		Get quote

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生物&药学活性

Oxythiamine chloride hydrochloride is a small molecule transketolase inhibitor with Kd of 33 nM, shows functional assay of human transketolase inhibition in HCT-116 cells with EC50 of 26 nM.
Oxythiamine induces G1 arrest in Ehrlich’s ascites tumor cells implanted in mice.

物理化学性质&存储条件

分子量	338.247
分子式	C12H17Cl2N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-hydroxy-2-methylpyrimidin-5-yl)methyl)-5-(2-hydroxyethyl)-4-methylthiazol-3-ium chloride hydrochloride

参考文献

1. Thomas AA, et al. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2206-10.

2. Tseng CW, et al. Cancer Res. 2018 Mar 29. pii: canres.2906.2017.

3. Ricciardelli C, et al. Clin Exp Metastasis. 2015 Jun;32(5):441-55.

4. Raïs B, et al. FEBS Lett. 1999 Jul 30;456(1):113-8.