Osilodrostat (LCI 699) | CYP11 B2 inhibitor | Probechem Biochemicals

Chemical Structure : Osilodrostat

CAS No.: 928134-65-0

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Osilodrostat (LCI699, LCI-699)

货号: PC-38385Not For Human Use, Lab Use Only.

Osilodrostat (LCI 699) is a potent, orally active inhibitor of human 11β-hydroxylase and aldosterone synthase (CYP11B2) with IC50 of 2.5 and 0.7 nM, respectively.

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5 mg	￥580	In stock
10 mg	￥880	In stock
25 mg	￥1280	In stock
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生物&药学活性

Osilodrostat (LCI 699) is a potent, orally active inhibitor of human 11β-hydroxylase and aldosterone synthase (CYP11B2) with IC50 of 2.5 and 0.7 nM, respectively.

Osilodrostat (LCI 699) reduces serum aldosterone, and has benefit in the treatment of hypertension.

物理化学性质&存储条件

分子量	227.237
分子式	C13H10FN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-4-(6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)-3-fluorobenzonitrile

参考文献

1. Amar L, et al. Hypertension. 2010 Nov;56(5):831-8.

2. Calhoun DA, et al. Circulation. 2011 Nov 1;124(18):1945-55.

3. Bertagna X, et al. J Clin Endocrinol Metab. 2014 Apr;99(4):1375-83.

Osilodrostat (LCI699, LCI-699)

生物&药学活性

物理化学性质&存储条件

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Osilodrostat (LCI699, LCI-699)

生物&药学活性

物理化学性质&存储条件

参考文献

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