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首页-小分子抑制剂&激动剂-GPCR-Neurokinin Receptor-Orvepitant
Orvepitant

Chemical Structure : Orvepitant

CAS No.: 579475-18-6

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Orvepitant (GW-823296, GW823296)

货号: PC-61552Not For Human Use, Lab Use Only.

Orvepitant (GW823296) is a potent and selective, brain penetrant NK1 receptor antagonist with pKi of 10.2.

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5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥4280 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Orvepitant (GW823296) is a potent and selective, brain penetrant NK1 receptor antagonist with pKi of 10.2.
Orvepitant exhibits an excellent, dose dependent inhibition of foot tapping in gerbils after oral administration with an ID50 of 0.11 mg/kg.
Orvepitant shows antidepressant effects.

物理化学性质&存储条件

分子量 628.623
分子式 C31H35F7N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,4S)-N-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-4-[(8aS)-hexahydro-6-oxopyrrolo[1,2-a]pyrazin-2(1H)-yl]-N-methyl-1-piperidinecarboxamide

参考文献

1. Di Fabio R, et al. Bioorg Med Chem. 2013 Nov 1;21(21):6264-73.

2. Ratti E, et al. J Psychopharmacol. 2013 May;27(5):424-34.

3. Trower MK, et al. Exp Dermatol. 2014 Nov;23(11):858-60.

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