Orteronel (TAK-700) | CYP17A1 inhibitor | Probechem Biochemicals

Chemical Structure : Orteronel

CAS No.: 566939-85-3

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Orteronel (TAK-700, TAK700)

货号: PC-42626Not For Human Use, Lab Use Only.

Orteronel (TAK-700) is a highly selective CYP17A1 (17,20-lyase) inhibitor with IC50 of 17 nM for human 17,20-lyase.

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5 mg	￥880	In stock
10 mg	￥1380	In stock
25 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

Orteronel (TAK-700) is a highly selective CYP17A1 (17,20-lyase) inhibitor with IC50 of 17 nM for human 17,20-lyase.
Orteronel (TAK-700) shows no activity on CYP3A4 (IC50>10 uM) and CYP11B1 (IC50>1 uM).
Orteronel (TAK-700) reduces both serum testosterone and dehydroepiandrosterone concentrations in monkey model at a dose of 1mg/kg.

物理化学性质&存储条件

分子量	307.3465
分子式	C18H17N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Naphthalenecarboxamide, 6-[(7S)-6,7-dihydro-7-hydroxy-5H-pyrrolo[1,2-c]imidazol-7-yl]-N-methyl-

参考文献

1. Kaku T, et al. Bioorg Med Chem. 2011 Nov 1;19(21):6383-99.

2. Yamaoka M, et al. J Steroid Biochem Mol Biol. 2012 Apr;129(3-5):115-28.

3. Dreicer R, et al. Clin Cancer Res. 2014 Mar 1;20(5):1335-44.

Orteronel (TAK-700, TAK700)

生物&药学活性

物理化学性质&存储条件

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Orteronel (TAK-700, TAK700)

生物&药学活性

物理化学性质&存储条件

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