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首页-小分子抑制剂&激动剂-Others-Other Targets-Orpinolide
Orpinolide

Chemical Structure : Orpinolide

CAS No.:

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Orpinolide

货号: PC-22607Not For Human Use, Lab Use Only.

Orpinolide is a synthetic withanolide analog with potent antileukemic properties, directly targets oxysterol-binding protein OSBP, disrupts Golgi homeostasis via a mechanism that requires active phosphatidylinositol 4-phosphate (PtdIns4P, PI4P) signaling at ER-Golgi membrane interface.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Orpinolide is a synthetic withanolide analog with potent antileukemic properties, directly targets oxysterol-binding protein OSBP, disrupts Golgi homeostasis via a mechanism that requires active phosphatidylinositol 4-phosphate (PtdIns4P, PI4P) signaling at ER-Golgi membrane interface.

物理化学性质&存储条件

分子量 483.69
分子式 C30H45NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-6-((S)-1-((3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)ethyl)-4-morpholino-5,6-dihydro-2H-pyran-2-one

参考文献

1. Marko Cigler, et al. Nat Chem Biol. 2024 Jun 21. doi: 10.1038/s41589-024-01614-4.

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