Org OD 02-0 (10-ethenyl-19-norprogesterone)

Chemical Structure : Org OD 02-0

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货号: PC-28148Not For Human Use, Lab Use Only.

Org OD 02-0 (10-ethenyl-19-norprogesterone) is a potent, selective membrane progesterone receptor alpha (mPRα) agonist with binding IC50 of 33.9 nM, mimicks the stimulatory actions of the endogenous progestin.

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50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Org OD 02-0 (10-ethenyl-19-norprogesterone) is a potent, selective membrane progesterone receptor alpha (mPRα) agonist with binding IC50 of 33.9 nM, mimicks the stimulatory actions of the endogenous progestin.
Org OD 02-0 significantly decreases cell death and apoptosis in response to serum starvation in breast cancer cells.
Org OD 02-0 shows high binding affinity for the progesterone receptor on HUVEC membranes, whereas nuclear PR (nPR) agonists R5020 and medroxyprogesterone acetate displays low binding affinities.
Org OD 02-0 (20 nM) also significantly increased endothelial nitric oxide synthase (eNOS) activity and eNOS phosphorylation in HUVECs.

物理化学性质&存储条件

分子量	326.48
分子式	C22H30O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	10-Ethenyl-19-norpregn-4-ene-3,20-dione

参考文献

1. Kelder J, et al. Steroids. 2010 Apr;75(4-5):314-22.

2. Camilletti MA, et al. Endocr Relat Cancer. 2019 May;26(5):497-510.

3. Dressing GE, et al. Horm Cancer. 2012 Jun;3(3):101-12.

4. Thomas P, et al. Endocrinology. 2014 Mar;155(3):1107-19.