Org 34167 | HCN Channel inhibitor | Probechem Biochemicals

Chemical Structure : Org 34167

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Org 34167 (Org 34,167)

货号: PC-20860Not For Human Use, Lab Use Only.

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1 g		Get quote

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生物&药学活性

Org 34167 is a broad-spectrum inhibitor of HCN channels with IC50 of 23.4, 8.2 and 9.2 uM for HCN1, HCN2 and HCN4 channels, respectively, slowing activation and causing a hyperpolarising shift in voltage-dependence of activation.
Org 34,167 (30 µM) significantly reduced I h-mediated sag in layer V mPFC pyramidal neurons in female BALB/c mice.
Org 34167 (0.5 mg/kg) reduced marble burying and increased the time spent mobile in the Porsolt swim and tail suspension tests in both male and female BALB/c mice.
Org 34,167 is effective at reducing depressive behaviours in mouse behavioural assays.

物理化学性质&存储条件

分子量	264.33
分子式	C17H16N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	C=CC[C@@H](C1=CC=CC=C1C2=NOC3=CC=CC=C23)N

参考文献

1. Paulo Pinares-Garcia, et al. Front Pharmacol. 2023 May 10;14:1159527.

2. Samotaeva IS, et al. Neuroscience. 2013 Jan 29;230:50-5.

Org 34167 (Org 34,167)

生物&药学活性

物理化学性质&存储条件

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Org 34167 (Org 34,167)

生物&药学活性

物理化学性质&存储条件

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