Org 26576 | AMPAR PAM | Probechem Biochemicals

Chemical Structure : Org 26576

CAS No.: 1026791-61-6

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Org 26576 (MK 8777, SCH 900777)

货号: PC-61723Not For Human Use, Lab Use Only.

Org 26576 (MK 8777, SCH 900777) is a potent AMPA receptor (AMPAR) positive allosteric modulator EC50 of 8-16 uM in rat hippocampal primary cultured neurons.

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25 mg	￥2180	In stock
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生物&药学活性

Org 26576 (MK 8777, SCH 900777) is a potent AMPA receptor (AMPAR) positive allosteric modulator EC50 of 8-16 uM in rat hippocampal primary cultured neurons.
Org 26576 (MK 8777, SCH 900777) potentiates rat hippocampal AMPA receptor responses in an exposure-dependant manner (0.1-10 mg/kg, i.v.).
Org 26576 (MK 8777, SCH 900777) increases BDNF release and enhanced neuronal differentiation and survival.
Org 26576 (MK 8777, SCH 900777) is an antidepressant has been halted due to a failed Phase II trial for major depressive disorder.

物理化学性质&存储条件

分子量	204.23
分子式	C11H12N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-3,4-Propano-2,3-dihydropyrido[3,2-f][1,4]oxazepine-5(4H)-one

参考文献

1. Jordan GR, et al. Neuropharmacology. 2005 Aug;49(2):254-64.

2. Su XW, et al. Psychopharmacology (Berl). 2009 Oct;206(2):215-22.

3. Bursi R, et al. Psychopharmacology (Berl). 2011 Dec;218(4):713-24.

Org 26576 (MK 8777, SCH 900777)

生物&药学活性

物理化学性质&存储条件

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Org 26576 (MK 8777, SCH 900777)

生物&药学活性

物理化学性质&存储条件

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