Org 25935 | GlyT1 inhibitor | Probechem Biochemicals

Chemical Structure : Org 25935

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Org 25935 (Org25935;Org-25935;SCH 900435)

货号: PC-60444Not For Human Use, Lab Use Only.

Org 25935 (SCH 900435) is a potent, selective glycine transporter 1 (GlyT1) inhibitor with IC50 of 100 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Org 25935 (SCH 900435) is a potent, selective glycine transporter 1 (GlyT1) inhibitor with IC50 of 100 nM.
Org 25935 (SCH 900435) shows negligible action on GlyT2.
Org 25935 (SCH 900435) produces a robust and dose-dependent decrease in EtOH consumption in rats, reduces compulsive relapse-like drinking without the development of tolerance.

物理化学性质&存储条件

分子量	339.427
分子式	C21H25NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	cis-N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl methyl)amino methylcarboxylic acid

参考文献

1. Molander A, et al. Alcohol Alcohol. 2007 Jan-Feb;42(1):11-8.

2. Morita K, et al. J Pharmacol Exp Ther. 2008 Aug;326(2):633-45.

3. Lidö HH, et al. Alcohol Clin Exp Res. 2009 Jul;33(7):1151-7.

4. Vengeliene V, et al. Biol Psychiatry. 2010 Oct 15;68(8):704-11.

Org 25935 (Org25935;Org-25935;SCH 900435)

生物&药学活性

物理化学性质&存储条件

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Org 25935 (Org25935;Org-25935;SCH 900435)

生物&药学活性

物理化学性质&存储条件

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