Oprozomib (ONX-0912, PR-047) | Proteasome inhibitor | Probechem Biochemicals

Chemical Structure : Oprozomib

CAS No.: 935888-69-0

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Oprozomib (ONX-0912, ONX0912, PR-047, PR047)

货号: PC-42896Not For Human Use, Lab Use Only.

Oprozomib (ONX-0912, PR-047) is a potent, orally bioavailable proteasome inhibitor that inhibits chymotrypsin-like (CT-L) activity of 20S proteasome β5/LMP7 with IC50 of 36/82 nM.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

Oprozomib (ONX-0912, PR-047) is a potent, orally bioavailable proteasome inhibitor that inhibits chymotrypsin-like (CT-L) activity of 20S proteasome β5/LMP7 with IC50 of 36/82 nM.
Oprozomib triggers apoptosis in MM cells, associated with PARP cleavage and caspase activation, causes in vitro and in vivo cytotoxicity in multiple myeloma.
Oprozomib also enhances anti-MM activity of bortezomib, lenalidomide dexamethasone, or pan-histone deacetylase inhibitor.

物理化学性质&存储条件

分子量	532.6092
分子式	C25H32N4O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 50 mg/mL
Chemical Name/SMILES	L-Serinamide, O-methyl-N-[(2-methyl-5-thiazolyl)carbonyl]-L-seryl-O-methyl-N-[(1S)-2-[(2R)-2-methyl-2-oxiranyl]-2-oxo-1-(phenylmethyl)ethyl]-

参考文献

1. Verbrugge SE, et al. J Pharmacol Exp Ther. 2012 Apr;341(1):174-82.

2. Chauhan D, et al. Blood. 2010 Dec 2;116(23):4906-15.

3. Zhou HJ, et al. J Med Chem. 2009 May 14;52(9):3028-38.

4. Hurchla MA, et al. Leukemia. 2013 Feb;27(2):430-40.

Oprozomib (ONX-0912, ONX0912, PR-047, PR047)

生物&药学活性

物理化学性质&存储条件

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Oprozomib (ONX-0912, ONX0912, PR-047, PR047)

生物&药学活性

物理化学性质&存储条件

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