Ophiobolin A | Calmodulin inhibitor | Probechem Biochemicals

Chemical Structure : Ophiobolin A

CAS No.: 4611-05-6

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Ophiobolin A (OphA)

货号: PC-72370Not For Human Use, Lab Use Only.

Ophiobolin A (OphA) is a potent, covalent CaM inhibitor, with broad toxicity against plants, microbes, and cancer cells, OphA also is a K-Ras4B but not an H-Ras selective inhibitor.

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1 mg	￥2180	In stock
5 mg	￥5980	In stock
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25 mg		Get quote

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生物&药学活性

Ophiobolin A (OphA) is a potent, covalent calmodulin (CaM) inhibitor, with broad toxicity against plants, microbes, and cancer cells, OphA also is a K-Ras4B but not an H-Ras selective inhibitor.
OphA disrupts membrane organization of K-Ras in a CaM-dependent manner and blocked the growth of cancer stem cell enriched spheroids derived from breast cancer cell lines.

物理化学性质&存储条件

分子量	400.559
分子式	C25H36O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Spiro[dicyclopenta[a,d]cyclooctene-3(2H),2′(3′H)-furan]-6-carboxaldehyde, 1,3a,4,4′,5′,6a,7,8,9,9a,10,10a-dodecahydro-9-hydroxy-3′,9,10a-trimethyl-5′-(2-methyl-1-propen-1-yl)-7-oxo-, (2′S,3′S,3aR,5′R,6aS,9R,9aS,10aR)-

参考文献

1. Au TK, Chick WS, Leung PC. Life Sci. 2000 Jul 7; 67(7):733-42.

2. Leung PC, Taylor WA, Wang JH, Tipton CL. J Biol Chem. 1984 Mar 10; 259(5):2742-7.

3. Najumudeen AK, et al. Oncogene. 2016 Oct 6; 35(40):5248-5262.

Ophiobolin A (OphA)

生物&药学活性

物理化学性质&存储条件

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Ophiobolin A (OphA)

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物理化学性质&存储条件

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