Opaganib hydrochloride (ABC294640) | SphK2 inhibitor | Probechem Biochemicals

Chemical Structure : Opaganib hydrochloride

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Opaganib hydrochloride (ABC294640 hydrochloride, ABC-294640 hydrochloride)

货号: PC-60525Not For Human Use, Lab Use Only.

ABC294640 (Opaganib) hydrochloride is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM.

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生物&药学活性

ABC294640 (Opaganib) hydrochloride is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM.
ABC294640 (Opaganib) shows no activity against SphK-1 with IC50 of >100 uM.
ABC294640 (Opaganib) attenuates S1P formation in intact cells, suppresses the proliferation of a broad panel of tumor cell lines, and inhibits tumor cell migration concomitant with loss of microfilaments.
ABC294640 (Opaganib) demonstrates antitumor activity in adenocarcinoma xenograft models.

物理化学性质&存储条件

分子量	417.374
分子式	C23H26Cl2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide hydrochloride

参考文献

1. French KJ, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):129-39.

2. Maines LW, et al. Inflammopharmacology. 2010 Apr;18(2):73-85.

3. Beljanski V, et al. J Pharmacol Exp Ther. 2010 May;333(2):454-64.

4. Antoon JW, et al. Endocrinology. 2010 Nov;151(11):5124-35.

Opaganib hydrochloride (ABC294640 hydrochloride, ABC-294640 hydrochloride)

生物&药学活性

物理化学性质&存储条件

参考文献

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Opaganib hydrochloride (ABC294640 hydrochloride, ABC-294640 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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