Opaganib (ABC294640) | SphK2 inhibitor | Probechem Biochemicals

Chemical Structure : Opaganib

CAS No.: 915385-81-8

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Opaganib (ABC294640, ABC-294640)

货号: PC-60524Not For Human Use, Lab Use Only.

Opaganib (ABC-294640, ABC294640) is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg	￥5980	In stock
250 mg		Get quote

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生物&药学活性

Opaganib (ABC294640) is a selective, competitive and orally bioavailable sphingosine kinase-2 (SphK-2) inhibitor with IC50 of 60 uM, Ki of 9.8 uM.
Opaganib (ABC294640) shows no activity against SphK-1 with IC50 of >100 uM.
Opaganib (ABC294640) attenuates S1P formation in intact cells, suppresses the proliferation of a broad panel of tumor cell lines, and inhibits tumor cell migration concomitant with loss of microfilaments.
Opaganib (ABC294640) demonstrates antitumor activity in adenocarcinoma xenograft models.

物理化学性质&存储条件

分子量	380.916
分子式	C23H25ClN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide

参考文献

1. French KJ, et al. J Pharmacol Exp Ther. 2010 Apr;333(1):129-39.

2. Maines LW, et al. Inflammopharmacology. 2010 Apr;18(2):73-85.

3. Beljanski V, et al. J Pharmacol Exp Ther. 2010 May;333(2):454-64.

4. Antoon JW, et al. Endocrinology. 2010 Nov;151(11):5124-35.

Opaganib (ABC294640, ABC-294640)

生物&药学活性

物理化学性质&存储条件

参考文献

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Opaganib (ABC294640, ABC-294640)

生物&药学活性

物理化学性质&存储条件

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