Opa1 inhibitor 0 (Opitor-0)

Chemical Structure : Opa1 inhibitor 0

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货号: PC-24926Not For Human Use, Lab Use Only.

Opa1 inhibitor 0 (Opitor-0) is a reversible, noncompetitive inhibitor of mitochondrial dynamin-related protein Optic Atrophy 1 (OPA1) with IC50 of 3.0 uM against GTPase activity, effectively induces mitochondrial fragmentation in both human and mouse cells.

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100 mg		Get quote
250 mg		Get quote

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生物&药学活性

Opa1 inhibitor 0 (Opitor-0) is a reversible, noncompetitive inhibitor of mitochondrial dynamin-related protein Optic Atrophy 1 (OPA1) with IC50 of 3.0 uM against GTPase activity, effectively induces mitochondrial fragmentation in both human and mouse cells.
Opitor-0 significantly more potent than MYLS22。
Opitor-0 enhances apoptotic mitochondrial cytochrome c release and restore breast cancer cell sensitivity to the Bcl-2 inhibitor ABT-737.
Opitor-0 reverts breast cancer cell resistance to Bcl-2 inhibition in MDA-MB-231 cells.

物理化学性质&存储条件

分子量	519.62
分子式	C30H25N5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-benzyl-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methyl-1-phenyl-1H-thieno[2,3-c]pyrazole-5-carboxamide

参考文献

1. Pellattiero A, et al. Sci Adv. 2025 Jul 4;11(27):eadx4562.