Onalespib | HSP90 inhibitor | Probechem Biochemicals

Chemical Structure : Onalespib

CAS No.: 912999-49-6

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Onalespib (AT13387, AT-13387)

货号: PC-25124Not For Human Use, Lab Use Only.

Onalespib (AT13387) is a highly potent HSP90 inhibitor with Ki of 0.71 nM by binding in the ATPase site at the N-terminus of Hsp90, inhibits HCT116 cell proliferation with IC50 of 48 nM.

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5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
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生物&药学活性

Onalespib (AT13387) is a highly potent HSP90 inhibitor with Ki of 0.71 nM by binding in the ATPase site at the N-terminus of Hsp90, inhibits HCT116 cell proliferation with IC50 of 48 nM.
Onalespib (AT13387) potently inhibits the expression of the oncogenic client proteins Raf-1 and CDK4 at 30 nM in the HCT116 cell line.
Onalespib (AT13387) potently inhibits the proliferation of a panel of human tumor cell lines (well over 100 cell lines have been tested), showing IC50 < 100 nM.
Onalespib (AT13387) (60 mg/kg ip 3 days on and 3 days off for four cycles) exhibits in vivo antitumor activity in nude BALB/c mice bearing early stage HCT116 human colon carcinoma xenografts.

物理化学性质&存储条件

分子量	409.53
分子式	C24H31N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2,4-Dihydroxy-5-isopropylphenyl)(5-((4-methylpiperazin-1-yl)methyl)isoindolin-2-yl)methanone

参考文献

1. Woodhead AJ, et al. J Med Chem. 2010 Aug 26;53(16):5956-69.

Onalespib (AT13387, AT-13387)

生物&药学活性

物理化学性质&存储条件

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Onalespib (AT13387, AT-13387)

生物&药学活性

物理化学性质&存储条件

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