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首页-小分子抑制剂&激动剂-GPCR-Prostaglandin Receptor-Omidenepag
Omidenepag

Chemical Structure : Omidenepag

CAS No.: 1187451-41-7

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Omidenepag (UR-7276, UR7276)

货号: PC-35402Not For Human Use, Lab Use Only.

Omidenepag (UR-7276) is a potent, selective agonist human EP2 receptor with binding IC50/EC50 of 10/1.7 nM, >500-fold selectivity over EP1, EP3 and EP4 receptors.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Omidenepag (UR-7276) is a potent, selective agonist human EP2 receptor with binding IC50/EC50 of 10/1.7 nM, >500-fold selectivity over EP1, EP3 and EP4 receptors.
Omidenepag is the active form of Omidenepag Isopropyl (OMDI).

物理化学性质&存储条件

分子量 478.527
分子式 C23H22N6O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(6-((4-(Pyrazol-1-yl)benzyl)(pyridin-3-ylsulfonyl)aminomethyl)pyridin-2-ylamino)acetic acid

参考文献

1. Kirihara T, et al. Invest Ophthalmol Vis Sci. 2018 Jan 1;59(1):145-153.

2. Impagnatiello F, et al. Br J Pharmacol. 2018 Apr 18. doi: 10.1111/bph.14328.

3. Fuwa M, et al. J Ocul Pharmacol Ther. 2018 Jul 10. doi: 10.1089/jop.2017.0146.

4. Iwamura R, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.8b00808.

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