Omapatrilat (BMS-186716) | ACE/NCP inhibitor | Probechem Biochemicals

Chemical Structure : Omapatrilat

CAS No.: 167305-00-2

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Omapatrilat (BMS-186716, BMS186716)

货号: PC-45435Not For Human Use, Lab Use Only.

Omapatrilat (BMS-186716) is a potent, dual inhibitor of the metalloproteases ACE and NEP with Ki of 0.64 nM and 0.45 nM, respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1280	In stock
25 mg	￥2280	In stock
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100 mg		Get quote

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生物&药学活性

Omapatrilat (BMS-186716) is a potent, dual inhibitor of the metalloproteases ACE and NEP with Ki of 0.64 nM and 0.45 nM, respectively.
Omapatrilat (BMS-186716) shows moderate activity against APP, and low activity against ECE1.
Omapatrilat (BMS-186716) causes significant inhibition of plasma ACE and increases plasma renin activity, reduces blood pressure in spontaneously hypertensive rats; orally active.

物理化学性质&存储条件

分子量	408.5349
分子式	C19H24N2O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 31 mg/mL
Chemical Name/SMILES	7H-Pyrido[2,1-b][1,3]thiazepine-7-carboxylic acid, octahydro-4-[[(2S)-2-mercapto-1-oxo-3-phenylpropyl]amino]-5-oxo-, (4S,7S,10aS)-

参考文献

1. Robl JA, et al. J Med Chem. 1997 May 23;40(11):1570-7.

2. Fryer RM, et al. Br J Pharmacol. 2008 Mar;153(5):947-55.

3. Burrell LM, et al. Am J Hypertens. 2000 Oct;13(10):1110-6.

Omapatrilat (BMS-186716, BMS186716)

生物&药学活性

物理化学性质&存储条件

参考文献

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Omapatrilat (BMS-186716, BMS186716)

生物&药学活性

物理化学性质&存储条件

参考文献

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