Oltipraz |CAS:64224-21-1 Probechem Biochemicals

Chemical Structure : Oltipraz

CAS No.: 64224-21-1

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Oltipraz (RP 35972;NSC 347901)

货号: PC-43087Not For Human Use, Lab Use Only.

Oltipraz (RP 35972, NSC 347901) is a cancer chemopreventive agent with inhibitory effect on angiogenesis and tumor growth, inhibits insulin- or hypoxia-induced HIF-1α expression through an increase in ubiquitination.

规格	价格	库存
10 mg (Free Sample)	￥280	In stock
50 mg	￥880	In stock
100 mg	￥1280	In stock
250 mg	￥1980	In stock
1 g		Get quote

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生物&药学活性

Oltipraz (RP 35972, NSC 347901) is a cancer chemopreventive agent with inhibitory effect on angiogenesis and tumor growth, inhibits insulin- or hypoxia-induced HIF-1α expression through an increase in ubiquitination.
Oltipraz (RP 35972, NSC 347901) abrogates insulin-induced H(2)O(2) production, thereby preventing H(2)O(2)-enhanced HIF-1alpha expression and promoting its ubiquitination and degradation.
Oltipraz (RP 35972, NSC 347901) inhibits HIF-1α activity and HIF-1α-dependent tumor growth both in vitro and in vivo.

物理化学性质&存储条件

分子量	226.3416
分子式	C8H6N2S3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3H-1,2-Dithiole-3-thione, 4-methyl-5-(2-pyrazinyl)-

参考文献

1. Lee WH, et al. Mol Cancer Ther. 2009 Oct;8(10):2791-802.

2. Kang SG, et al. Carcinogenesis. 2012 Mar;33(3):661-9.

3. Lee YH, et al. Bioorg Med Chem. 2016 Jun 15;24(12):2843-51.

Oltipraz (RP 35972;NSC 347901)

生物&药学活性

物理化学性质&存储条件

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Oltipraz (RP 35972;NSC 347901)

生物&药学活性

物理化学性质&存储条件

参考文献

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